EEG/LFP Workshop University of Reading University of Sheffield BBSRC Experimental Psychology Society

About the Workshop

Recent intracellular studies have shown that the excitatory and inhibitory conductances of neocortical neurons co-tune in response to sensory stimulation (Wehr and Zador 2003, Haider et al 2006, Higley and Contreras 2006, Okun and Lampl 2008, Atallah and Scanziani, 2009, Zhou et al 2014). Applying this principle to populations of neurons, it has been shown that evoked local field potentials in layer IV barrel cortex of rodents may be separated into excitatory and inhibitory components (Zheng et al 2012). Through mathematical models this result can be extended to the supragranular cortical layer and EEG recordings (Luo 2014).

Understanding the neural genesis of EEG in terms of neural excitation and inhibition will greatly enhance our ability to interpret EEG recordings, making it possible to study, non-invasively, brain diseases in which the balance between neural excitation and inhibition is disrupted. Hence this workshop aims to bring together researchers working in these diverse fields with a common goal of investigating balanced neural excitation and inhibition, and to discuss how work in this area may contribute towards a better understanding of neurological diseases such as epilepsy, autism and schizophrenia, and neurodegenerative diseases such as Alzheimer's.

References

  • Atallah, B.V., Scanziani, M., 2009. Instantaneous modulation of gamma oscillation frequency by balancing excitation with inhibition. Neuron 62, 566–577
  • Haider, B., Duque, A., Hasenstaub, A.R., McCormick, D.A., 2006. Neocortical network activity in vivo is generated through a dynamic balance of excitation and inhibition. J. Neurosci. 26, 4535–4545
  • Higley, M.J., Contreras, D., 2006. Balanced excitation and inhibition determine spike timing during frequency adaptation. J. Neurosci. 26, 448–457
  • Luo, J.J. 2014. Modelling evoked local field potentials: an investigation into balanced synaptic excitation and inhibition. PhD thesis
  • Okun, M., Lampl, I., 2008. Instantaneous correlation of excitation and inhibition during ongoing and sensory-evoked activities. Nat. Neurosci. 11, 535–537
  • Wehr, M., Zador, A.M., 2003. Balanced inhibition underlies tuning and sharpens spike timing in auditory cortex. Nature 426, 442–446
  • Zheng, Y., Luo, J.J., Harris, S., Kennerley, A., Berwick, J., Billings, S.A., Mayhew, J.E.W. 2012. Balanced excitation and inhibition: Model based analysis of local field potentials. NeuroImage 63, 81-94
  • Zhou, M., Liang, F., Xiong, X.R., Li, L., Li, H., Xiao, Z., Tao, H.W. & Zhang, L.I., 2014. Scaling down of balanced excitation and inhibition by active behavioural states in auditory cortex. Nature Neuroscience 7(6), 840-852

Affiliated centres and laboratories